H2N2V1, Main, Exploration, bibRecord, 000178

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

Identifieur interne : 000178 ( Main/Exploration ); précédent : 000177; suivant : 000179

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

Auteurs : D. Korenkov [Russie, Australie] ; T. H. O. Nguyen [Australie] ; I. Isakova-Sivak [Russie] ; T. Smolonogina [Russie] ; L. E. Brown [Australie] ; K. Kedzierska [Australie] ; L. Rudenko [Russie]

Source :

Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2018.

RBID : PMC:5893192

Abstract

ABSTRACT

Live attenuated influenza vaccines (LAIV) induce CD8⁺ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8⁺ T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an in vitro model.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893192

DOI: 10.1080/21645515.2017.1417713
PubMed: 29252117
PubMed Central: 5893192

Affiliations:

Australie, Russie

Le document en format XML

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 T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an <italic>in vitro</italic>
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Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

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Abstract

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